The European AIDS Clinical Society (EACS) invites you to join the 21st European AIDS Conference, taking place from 6–9 October 2027 in Prague, Czechia. Bringing together clinicians, researchers, community representatives and activists from around the world, EACS 2027 will offer an inspiring scientific programme in one of Europe’s most vibrant and historic cities. The conference will feature keynote and plenary lectures by leading experts, highlighting the latest advances and emerging topics in HIV medicine, prevention and care. EACS 2027 will also provide a dynamic platform for collaboration, knowledge exchange and networking across disciplines and communities committed to improving HIV science and patient care worldwide.